Sören Krach

Complexity in disguise: a systematic review of fractal analysis in psychiatric neuroimaging Marta Reales-Moreno, Alexandra Korda and Stefan Borgwardt DOI: 10.1007/s00330-026-12630-4 Abstract Objectives Psychiatric diagnosis and fractal studies are complex processes that extend beyond clinical evaluation andrequire careful methodological considerations in neuroimaging. Over the years, fractals have helped reduce thesecomplexities in research, but they still […]

Empirical validation of race-neutral normative brain morphometry models across ethnoracially diverse populations Ruiyang Ge, Yuetong Yu, Faye New, Shalaila S. Haas, Nicole Sanford, Kevin Yu, Paul Allen, Seda Arslan, Mihai Avram, Stefan Borgwardt, … DOI: 10.1073/pnas.2521055123 Abstract Normative models of brain morphometry quantify individual deviations from typicalanatomical patterns and hold promise for enhancing clinical decision-making. However,their

Neuroplastic white matter changes in patients with major depression following lysergic acid diethylamide treatment Mihai Avram, Aurore Menegaux, Felix Müller, Hannes Zaczek, Alexandra Korda, Helena Rogg, Anna M. Becker, Laura Ley, Matthias E. Liechti, and Stefan Borgwardt DOI: 10.1016/j.xcrm.2026.1027911055/a-2813-6755 Abstract The clinical trial NCT03866252 investigates the antidepressant effects of lysergic acid diethylamide (LSD) in 61 patients with

Klinische Routinedaten und innovative Therapieansätze – Implikationen für die Weiterentwicklung der Psychiatrie und Neuropsychiatrie Stefan Borgwardt DOI: 10.1055/a-2813-6755 Abstract Die aktuelle psychiatrisch und neuropsychiatrische Versorgung ist zunehmend durch eine deutliche Zunahme multimorbider, hochkomplexer Krankheitsverläufe geprägt. Zwei Beiträge der vorliegenden Ausgabe illustrieren exemplarisch, wie sowohl methodisch robuste Auswertungen von klinischen Routinedaten als auch explorative, nicht-pharmakologische Therapieansätze

Local chemoarchitecture explains widespread lower cortical thickness associated with clinical high risk for psychosis Xi Yang, Ingrid Agartz, Ole Andreassen, Peter Bachman, Inmaculada Baeza, Cali Bartholomeusz, Stefan Borgwardt, … DOI: 10.1038/s41380-026-03586-4 Abstract The Clinical High Risk (CHR) state for psychosis is consistently associated with widespread cortical thinning. However, the underlying mechanisms driving this neuroanatomical phenotype remain

Zusammenhänge von Veränderungen psychischer Flexibilität und Veränderungen psychischer Gesundheit: Eine Netzwerkanalyse Boris Jakov Entus, Nele Assmann, Catarina Newe, Eva Fassbinder, Hans Anton Huth, Stefan Borgwardt, Jan Philipp Klein DOI: 10.1055/a-2768-2149 Abstract Zielsetzung Psychische Flexibilität gilt als wichtiger Mechanismus zur Förderung psychischer Gesundheit. Diese Studie untersuchte mithilfe von Netzwerkanalysen Zusammenhänge zwischen den sechs Flexibilitätsprozessen der ACT

Biosignatures of cognitive basic symptoms mark a distinct neurodevelopmental pathway to schizophrenia Nikolaos Koutsouleris, Clara Vetter, … ,  Alexandra Korda, Alessandro Bertolino, Stefan Borgwardt, … DOI: 10.1093/brain/awag100 Abstract Efforts to predict schizophrenia risk using biological data have been hampered by the heterogeneity of current “clinical-high-risk” (CHR-P) criteria, which pool phenomenologically and biologically distinct syndromes under

Evidence of phenotypes indexing cognitive resilience and vulnerability in the early course of mood and psychosis spectrum illness; mapping the latent structure, characteristics, and longitudinal stability of cognitive heterogeneity Tamsyn E Van Rheenen, Elysha Ringin, … , Stefan Borgwardt, …  DOI: 10.1016/j.euroneuro.2026.112800 Abstract The latent structure and longitudinal stability of cognitive heterogeneity during the early

Task-aware multiple instance learning for stress detection from facial video data Nele Sophie Brügge, Alexandra Korda, Heinz Handels & Giorgos Giannakakis  DOI: 10.1016/j.jad.2026.121472 Abstract Stress is a prevalent condition linked to a wide range of mental and physical health disorders. Timely detection of stress is critical for enabling early interventions and promoting long-term well-being. Traditional

Brain texture alterations predict subtle visualperceptual dysfunctions in recent onset psychosisand clinical high-risk state Rebekka Lencer, … , Stefan Borgwardt, Christina Andreou, Alexandra Korda & the PRONIA Consortium  DOI: 10.1038/s41398-026-03840-x Abstract Deeper understanding of Subtle Visual Dysfunctions (VisDys) in the early stage of mental illness and their neurobiological underpinnings, as reflected by microstructural brain texture