Sören Krach

Klinische Routinedaten und innovative Therapieansätze – Implikationen für die Weiterentwicklung der Psychiatrie und Neuropsychiatrie Stefan Borgwardt DOI: 10.1055/a-2813-6755 Abstract Die aktuelle psychiatrisch und neuropsychiatrische Versorgung ist zunehmend durch eine deutliche Zunahme multimorbider, hochkomplexer Krankheitsverläufe geprägt. Zwei Beiträge der vorliegenden Ausgabe illustrieren exemplarisch, wie sowohl methodisch robuste Auswertungen von klinischen Routinedaten als auch explorative, nicht-pharmakologische Therapieansätze […]

Local chemoarchitecture explains widespread lower cortical thickness associated with clinical high risk for psychosis Xi Yang, Ingrid Agartz, Ole Andreassen, Peter Bachman, Inmaculada Baeza, Cali Bartholomeusz, Stefan Borgwardt, … DOI: 10.1038/s41380-026-03586-4 Abstract The Clinical High Risk (CHR) state for psychosis is consistently associated with widespread cortical thinning. However, the underlying mechanisms driving this neuroanatomical phenotype remain

Zusammenhänge von Veränderungen psychischer Flexibilität und Veränderungen psychischer Gesundheit: Eine Netzwerkanalyse Boris Jakov Entus, Nele Assmann, Catarina Newe, Eva Fassbinder, Hans Anton Huth, Stefan Borgwardt, Jan Philipp Klein DOI: 10.1055/a-2768-2149 Abstract Zielsetzung Psychische Flexibilität gilt als wichtiger Mechanismus zur Förderung psychischer Gesundheit. Diese Studie untersuchte mithilfe von Netzwerkanalysen Zusammenhänge zwischen den sechs Flexibilitätsprozessen der ACT

Biosignatures of cognitive basic symptoms mark a distinct neurodevelopmental pathway to schizophrenia Nikolaos Koutsouleris, Clara Vetter, … ,  Alexandra Korda, Alessandro Bertolino, Stefan Borgwardt, … DOI: 10.1093/brain/awag100 Abstract Efforts to predict schizophrenia risk using biological data have been hampered by the heterogeneity of current “clinical-high-risk” (CHR-P) criteria, which pool phenomenologically and biologically distinct syndromes under

Evidence of phenotypes indexing cognitive resilience and vulnerability in the early course of mood and psychosis spectrum illness; mapping the latent structure, characteristics, and longitudinal stability of cognitive heterogeneity Tamsyn E Van Rheenen, Elysha Ringin, … , Stefan Borgwardt, …  DOI: 10.1016/j.euroneuro.2026.112800 Abstract The latent structure and longitudinal stability of cognitive heterogeneity during the early

Task-aware multiple instance learning for stress detection from facial video data Nele Sophie Brügge, Alexandra Korda, Heinz Handels & Giorgos Giannakakis  DOI: 10.1016/j.jad.2026.121472 Abstract Stress is a prevalent condition linked to a wide range of mental and physical health disorders. Timely detection of stress is critical for enabling early interventions and promoting long-term well-being. Traditional

Brain texture alterations predict subtle visualperceptual dysfunctions in recent onset psychosisand clinical high-risk state Rebekka Lencer, … , Stefan Borgwardt, Christina Andreou, Alexandra Korda & the PRONIA Consortium  DOI: 10.1038/s41398-026-03840-x Abstract Deeper understanding of Subtle Visual Dysfunctions (VisDys) in the early stage of mental illness and their neurobiological underpinnings, as reflected by microstructural brain texture

Mental health outcomes in young adolescents born preterm reveal the need for earlier screening Emilia Greif, Frederike Schröpfer, Jekaterina Dudko, …, Stefan Borgwardt & Léon Franzen  DOI: 10.31234/osf.io/hv3xs_v1 Abstract Early adolescence marks a critical period for the onset of psychiatric symptoms, with 50% of mental disorders emerging before age 18. Recent evidence points to individuals

The Perception of Visual Distortions in Virtual Reality andTheir Association with Psychosis-Relevant Traits Fabian D. Mueller, … , Léon Franzen, …  DOI: 10.31234/osf.io/pfy6u_v2 Abstract Background Visual distortions (VDs) are frequently reported but insufficiently characterized in early psychosis and may reflect alterations in perceptual processing. Computational accounts emphasize aberrant precision-weighting of sensory evidence and prior expectations,

Psychedelics distinctly alter brain entropy and complexity compared to psychostimulants K. Larsen, … , S. Borgwardt, F. Holze, L. Ley, P. Vizeli, A. Klaiber, A.M. Becker, B. Ozenne, M. Avram, P.M. Fisher DOI: 10.64898/2026.01.15.26344193 Abstract Classical psychedelics have regained interest for their potential to treat psychiatric and neurological disorders, and explore neural mechanisms supporting perception,