Sören Krach

Mental health outcomes in young adolescents born preterm reveal the need for earlier screening Emilia Greif, Frederike Schröpfer, Jekaterina Dudko, …, Stefan Borgwardt & Léon Franzen  DOI: 10.31234/osf.io/hv3xs_v1 Abstract Early adolescence marks a critical period for the onset of psychiatric symptoms, with 50% of mental disorders emerging before age 18. Recent evidence points to individuals […]

The Perception of Visual Distortions in Virtual Reality andTheir Association with Psychosis-Relevant Traits Fabian D. Mueller, … , Léon Franzen, …  DOI: 10.31234/osf.io/pfy6u_v2 Abstract Background Visual distortions (VDs) are frequently reported but insufficiently characterized in early psychosis and may reflect alterations in perceptual processing. Computational accounts emphasize aberrant precision-weighting of sensory evidence and prior expectations,

Psychedelics distinctly alter brain entropy and complexity compared to psychostimulants K. Larsen, … , S. Borgwardt, F. Holze, L. Ley, P. Vizeli, A. Klaiber, A.M. Becker, B. Ozenne, M. Avram, P.M. Fisher DOI: 10.64898/2026.01.15.26344193 Abstract Classical psychedelics have regained interest for their potential to treat psychiatric and neurological disorders, and explore neural mechanisms supporting perception,

Neural Dynamics of Social Cognition: A Single-TrialComputational Analysis of Learning Under Uncertainty Colleen E Charlton, Daniel J Hauke, … ,  Stefan Borgwardt, …  DOI: 10.1002/hbm.70433 Abstract Understanding others’ intentions amidst uncertainty is critical for effective social interactions, yet the neural mechanisms under-lying this process are not fully understood. Here, we combined computational modeling and single-trial

The impact of premature birth and low birth weight on motor, visual, and cognitive skills and mental health in adolescence: a systematic review and meta-analysis Frederike Schröpfer, Emilia Greif, Sofia Eickhoff, … , Stefan Borgwardt & Léon Franzen  DOI: 10.1007/s00787-025-02937-w Abstract Mental disorders represent a significant challenge for individuals and society. Many of them have

Perspectives of mothers and fathers affected by addiction of an adolescent/adult child – results from a mixed-method study Anja Bischof, Richard Velleman, Stefan Borgwardt, Hans-Juergen Rumpf & Gallus Bischof DOI: 10.1186/s13690-025-01826-7 Abstract Background Addiction has an impact not only on the individual but also on family members. Stress and strain are high especially in parents

Mapping symptom dimensions in early psychosis through neurotransmitter-informed co-localization of structural and functional brain alterations L. Hahn, M. Sacha, … , S Borgwardt, …  DOI: 10.1016/j.nsa.2025.106605 Abstract Traditional diagnostic tools like the Positive and Negative Syndrome Scale for Schizophrenia (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS) assess broad symptom domains but

Mental health, coping and related risk factors during the first 2 years of the COVID-19 pandemic in children: Nationally representative, multi-wave, cross-sectional results from 12 countries from the global COH-FIT study Agorastos Agorastos, Trevor Thompson, … , Stefan Borgwardt, … DOI: 10.1016/j.euroneuro.2025.112741 Abstract Few multinational studies have assessed risk factors and coping strategies associated with

Multivariate Brain-Blood Signatures in Early-Stage Depression and Psychosis David Popovic, … , Stefan Borgwardt, Stephen J Wood, Eva Meisenzahl, Nikolaos Koutsouleris, Rachel Upthegrove, PRONIA Consortium  DOI: 10.1001/jamapsychiatry.2025.3803 Abstract Importance  Inflammation is increasingly implicated in the pathophysiology of mood and psychotic disorders. Integrating blood biomarkers and brain imaging may help uncover mechanistic pathways and guide targeted interventions.