Sören Krach

Evidence of phenotypes indexing cognitive resilience and vulnerability in the early course of mood and psychosis spectrum illness; mapping the latent structure, characteristics, and longitudinal stability of cognitive heterogeneity Tamsyn E Van Rheenen, Elysha Ringin, … , Stefan Borgwardt, …  DOI: 10.1016/j.euroneuro.2026.112800 Abstract The latent structure and longitudinal stability of cognitive heterogeneity during the early […]

Task-aware multiple instance learning for stress detection from facial video data Nele Sophie Brügge, Alexandra Korda, Heinz Handels & Giorgos Giannakakis  DOI: 10.1016/j.jad.2026.121472 Abstract Stress is a prevalent condition linked to a wide range of mental and physical health disorders. Timely detection of stress is critical for enabling early interventions and promoting long-term well-being. Traditional

Brain texture alterations predict subtle visualperceptual dysfunctions in recent onset psychosisand clinical high-risk state Rebekka Lencer, … , Stefan Borgwardt, Christina Andreou, Alexandra Korda & the PRONIA Consortium  DOI: 10.1038/s41398-026-03840-x Abstract Deeper understanding of Subtle Visual Dysfunctions (VisDys) in the early stage of mental illness and their neurobiological underpinnings, as reflected by microstructural brain texture

Mental health outcomes in young adolescents born preterm reveal the need for earlier screening Emilia Greif, Frederike Schröpfer, Jekaterina Dudko, …, Stefan Borgwardt & Léon Franzen  DOI: 10.31234/osf.io/hv3xs_v1 Abstract Early adolescence marks a critical period for the onset of psychiatric symptoms, with 50% of mental disorders emerging before age 18. Recent evidence points to individuals

The Perception of Visual Distortions in Virtual Reality andTheir Association with Psychosis-Relevant Traits Fabian D. Mueller, … , Léon Franzen, …  DOI: 10.31234/osf.io/pfy6u_v2 Abstract Background Visual distortions (VDs) are frequently reported but insufficiently characterized in early psychosis and may reflect alterations in perceptual processing. Computational accounts emphasize aberrant precision-weighting of sensory evidence and prior expectations,

Psychedelics distinctly alter brain entropy and complexity compared to psychostimulants K. Larsen, … , S. Borgwardt, F. Holze, L. Ley, P. Vizeli, A. Klaiber, A.M. Becker, B. Ozenne, M. Avram, P.M. Fisher DOI: 10.64898/2026.01.15.26344193 Abstract Classical psychedelics have regained interest for their potential to treat psychiatric and neurological disorders, and explore neural mechanisms supporting perception,

Neural Dynamics of Social Cognition: A Single-TrialComputational Analysis of Learning Under Uncertainty Colleen E Charlton, Daniel J Hauke, … ,  Stefan Borgwardt, …  DOI: 10.1002/hbm.70433 Abstract Understanding others’ intentions amidst uncertainty is critical for effective social interactions, yet the neural mechanisms under-lying this process are not fully understood. Here, we combined computational modeling and single-trial

The impact of premature birth and low birth weight on motor, visual, and cognitive skills and mental health in adolescence: a systematic review and meta-analysis Frederike Schröpfer, Emilia Greif, Sofia Eickhoff, … , Stefan Borgwardt & Léon Franzen  DOI: 10.1007/s00787-025-02937-w Abstract Mental disorders represent a significant challenge for individuals and society. Many of them have

Perspectives of mothers and fathers affected by addiction of an adolescent/adult child – results from a mixed-method study Anja Bischof, Richard Velleman, Stefan Borgwardt, Hans-Juergen Rumpf & Gallus Bischof DOI: 10.1186/s13690-025-01826-7 Abstract Background Addiction has an impact not only on the individual but also on family members. Stress and strain are high especially in parents

Mapping symptom dimensions in early psychosis through neurotransmitter-informed co-localization of structural and functional brain alterations L. Hahn, M. Sacha, … , S Borgwardt, …  DOI: 10.1016/j.nsa.2025.106605 Abstract Traditional diagnostic tools like the Positive and Negative Syndrome Scale for Schizophrenia (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS) assess broad symptom domains but