Publications

Basal-Forebrain Cholinergic Nuclei Alterations are Associated With Medication and Cognitive Deficits Across the Schizophrenia Spectrum Julia Schulz, … Stefan Borgwardt … & Mihai Avram   DOI: 10.1093/schbul/sbad118 Abstract Background and Hypothesis The cholinergic system is altered in schizophrenia. Particularly, patients’ volumes of basal-forebrain cholinergic nuclei (BFCN) are lower and correlated with attentional deficits. It is unclear, however, …

Basal-Forebrain Cholinergic Nuclei Alterations are Associated With Medication and Cognitive Deficits Across the Schizophrenia Spectrum Read More »

Effective-connectivity of thalamocortical interactions following d-amphetamine, LSD, and MDMA administration Mihai Avram … Helena Rogg, Alexandra Korda … & Stefan Borgwardt 2023, Biological Psychiatry DOI: doi.org/10.1016/j.bpsc.2023.07.010 Abstract Background While the exploration of serotonergic psychedelics as psychiatric medicines deepens, so does the pressure to better understand how these compounds act on the brain. Methods We used …

Effective-connectivity of thalamocortical interactions following d-amphetamine, LSD, and MDMA administration Read More »

In a recent radio interview with the NDR Stefan Borgwardt highlighted the wide-ranging support the Baltic Early Treatment Service (BEATS) Lübeck offers to help-seeking adolescents and adults aged 15-35. Referrals can be made by professionals but BEATS also considers self-referrals by help-seeking individuals. For more information on BEATS, please visit our subpage. More information on the …

NDR radio interview with Prof. Borgwardt on our early detection service BEATS Read More »

A recent article in The Zeit explores the evidence for the serotonin hypothesis of depression including an interview with Stefan Borgwardt. Specifically, it critically examines the evidence provided by a recent overview article questioning serotonin as a crucial neurotransmitter in the etiology of depression. However, as professor Borgwardt stated, for complex disorders such as depression, …

The serotonin hypothesis in depression – interview with Prof. Borgwardt Read More »

The non-specific nature of mental health and structural brain outcomes following childhood trauma Theresa K Haidl, …. Stefan Borgwardt  2023, Psychol Med DOI: 10.1017/S0033291721002439 Abstract Background: Childhood trauma (CT) is associated with an increased risk of mental health disorders; however, it is unknown whether this represents a diagnosis-specific risk factor for specific psychopathology mediated by …

The non-specific nature of mental health and structural brain outcomes following childhood trauma Read More »

Chaos analysis of the cortical boundary for the recognition of psychosis Alexandra I. Korda, Christina Andreou, Mihai Avram, Marina Frisman, …, Stefan Borgwardt  2023, J Psychiatry Neurosci DOI: https://doi.org/10.1503/jpn.220160 Abstract Background: Structural MRI studies in people with first-episode psychosis (FEP) and those in the clinical high-risk (CHR) state have consistently shown volumetric abnormalities that depict …

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Circadian rhythms in auditory hallucinations and psychosis Hong-Viet V Ngo, … Christina Andreou, …  2023, Acta Physiol DOI: 10.1111/apha.13944 Abstract Circadian rhythms are imprinted in all organisms and influence virtually all aspects of physiology and behavior in adaptation to the 24-h day-night cycle. This recognition of a circadian timekeeping system permeating essentially all healthy functioning …

Circadian rhythms in auditory hallucinations and psychosis. Read More »

Lysergic acid diethylamide: In search of the wonder drug  Mihai Avram, Felix Müller, Stefan Borgwardt  2023, Book: Psychedelics as psychiatric medications Link to the chapter

Effects of a probiotic add-on treatment on fronto-limbic brain structure, function, and perfusion in depression: Secondary neuroimaging findings of a randomized controlled trial  Gulnara Yamanbaeva, … Stefan Borgwardt, ….  2023, Journal of Affective Disorders DOI: 10.1016/j.jad.2022.12.142 Abstract Background: Probiotics are suggested to improve depressive symptoms via the microbiota-gut-brain axis. We have recently shown a beneficial clinical …

Effects of a probiotic add-on treatment on fronto-limbic brain structure, function, and perfusion in depression: Secondary neuroimaging findings of a randomized controlled trial Read More »

Brain activity during a working memory task after daily caffeine intake and caffeine withdrawal: a randomized double-blind placebo-controlled trial  Yu-Shiuan Lin, … Stefan Borgwardt, ….  2023, Scientific Reports DOI: 10.1038/s41598-022-26808-5 Abstract Acute caffeine intake has been found to increase working memory (WM)-related brain activity in healthy adults without improving behavioral performances. The impact of daily …

Brain activity during a working memory task after daily caffeine intake and caffeine withdrawal: a randomized double-blind placebo-controlled trial Read More »