Publications

Psychedelics tune the brain to the environment Stefan Borgwardt & Mihai Avram DOI: 10.1038/d41586-026-02377-9 Abstract Classic psychedelic compounds — a group that includes psilocybin, LSD, DMT and mescaline — induce profound alterations in perception, cognition and emotion. These substances have captured scientific and clinical attention, partly because guided treatment with psychedelics can provide rapid and […]

Copeptin as a predictor of relapse in patients withan acute psychotic episode: a prospective 1-yearfollow-up study Clara O. Sailer, Jennifer Marian, Cihan Atila, Cemile Bathelt, Stefan Borgwardt & Mirjam Christ-Crain DOI: 10.1038/s41398-026-04374-y Abstract Arginine vasopressin (AVP), involved in higher brain functions, is increased in individuals with acute psychosis. Copeptin, a stable surrogate marker of AVP,

Transdiagnostic signatures of nonlinear gray-matter organization in major psychiatric disorders Evelyn Reger, Rossitsa Paunova, Ulviyya Mammadova, Diyana Najar, Drozdstoy Stoyanov, Stefan Borgwardt & Alexandra Korda  DOI: 10.1140/epjs/s11734-026-02554-x Abstract Schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) are associated with structural brain abnormalities. Lyapunov-based approaches may provide additional descriptors of nonlinear gray-matter (GM) organization that might not be reflected by standard

Reliability of psychiatric diagnoses in the 21st century Mateo Boberg, Mads Gram Henriksen, … Léon Franzen, Stefan Borgwardt, … DOI: 10.3389/fpsyt.2026.1891625 Abstract Background:  Reliable diagnosis is a cornerstone of medical practice, yet concerns about diagnostic reliability have long haunted psychiatry. In the 1970s, the US–UK Diagnostic Project revealed striking international discrepancies in diagnostic practice. Although operationalized

Structural brain complexity is associated with linguistic complexity in psychosis Alexandra Korda, Wolfram Hinzen, Rui He, Peter van Dyken, Michael Mackinley, Eric Toyota, Mihai Avram, Christina Andreou, Stefan Borgwardt and Lena Palaniyappan To the article Abstract Introduction: Brain-structural and language abnormalities in people with psychotic symptoms (PSx)have long been reported. A key question is whether

Mental health outcomes in young adolescents born preterm reveal the need for earlier screening Emilia Greif, Frederike Schröpfer, Jekaterina Dudko, …, Stefan Borgwardt & Léon Franzen  DOI:  doi:10.1192/j.eurpsy.2026.12240 Abstract Early adolescence marks a critical period for the onset of psychiatric symptoms, with 50% of mental disorders emerging before age 18. Recent evidence points to individuals

Dopaminergic Drugs Modulate Resting-State EEG Microstates in Healthy Participants Renate de Bock, Amatya J. Mackintosh, Alexandra Korda, Alina Preuss, Daniel J. Hauke, Andreea O. Diaconescu, Philipp Sterzer, Stefan Borgwardt, Christina Andreou DOI: 10.1007/s10548-026-01232-4 Abstract Changes in the temporal parameters of EEG microstates are observed in various psychiatric illnesses, including psychotic disorders. These changes have also

Disentanglement learning to deconfound neuroimaging-environmental data: application to multi-site data harmonization in psychiatry Ines W. Sampaio, Anna M. Bianchi, Stefan Borgwardt, … DOI: 10.1109/ACCESS.2026.3712218 Abstract Debiasing and deconfounding represent fundamental challenges in deep learning (DL) applications to neuroimaging data, where confounding effects can significantly compromise model reliability and generalizability. Traditional debiasing approaches often require preprocessing

Complexity in disguise: a systematic review of fractal analysis in psychiatric neuroimaging Marta Reales-Moreno, Alexandra Korda and Stefan Borgwardt DOI: 10.1007/s00330-026-12630-4 Abstract Objectives Psychiatric diagnosis and fractal studies are complex processes that extend beyond clinical evaluation andrequire careful methodological considerations in neuroimaging. Over the years, fractals have helped reduce thesecomplexities in research, but they still

Empirical validation of race-neutral normative brain morphometry models across ethnoracially diverse populations Ruiyang Ge, Yuetong Yu, Faye New, Shalaila S. Haas, Nicole Sanford, Kevin Yu, Paul Allen, Seda Arslan, Mihai Avram, Stefan Borgwardt, … DOI: 10.1073/pnas.2521055123 Abstract Normative models of brain morphometry quantify individual deviations from typicalanatomical patterns and hold promise for enhancing clinical decision-making. However,their