Publications

Alterations of Functional Connectivity Dynamics in Affective and Psychotic Disorders Linnea Hoheisel, … Stefan Borgwardt, … PRONIA Consortium   DOI: 10.1016/j.bpsc.2024.02.013 Abstract Background Psychosis and depression patients exhibit widespread neurobiological abnormalities. The analysis of dynamic functional connectivity (dFC), allows for the detection of changes in complex brain activity patterns, providing insights into common and unique processes underlying these …

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  Aging effects on the encoding/retrieval flip in associative memory: fMRI evidence from incidental contingency learning Else Schneider, … Stefan Borgwardt, …  DOI: 10.3389/fnagi.2024.1357695 Summary Associative memory is arguably the most basic memory function and therein constitutes the foundation of all episodic and semantic memory processes. At the same time, the decline of associative memory represents …

Aging effects on the encoding/retrieval flip in associative memory: fMRI evidence from incidental contingency learning Read More »

Normative modelling of brain morphometry across the lifespan with CentileBrain: algorithm benchmarking and model optimisation Ruiyang Ge, … Stefan Borgwardt, …   DOI: 10.1016/S2589-7500(23)00250-9 Summary The value of normative models in research and clinical practice relies on their robustness and a systematic comparison of different modelling algorithms and parameters; however, this has not been done to …

Normative modelling of brain morphometry across the lifespan with CentileBrain: algorithm benchmarking and model optimisation Read More »

Altered Perception of Environmental Volatility During Social Learning in Emerging Psychosis Daniel J. Hauke, … Christina Andreou, … Stefan Borgwardt, …  DOI: 10.5334/cpsy.95 Abstract Paranoid delusions or unfounded beliefs that others intend to deliberately cause harm are a frequent and burdensome symptom in early psychosis, but their emergence and consolidation still remains opaque. Recent theories …

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Management of treatment resistance-Treatment-resistant schizophrenia Elias Wagner, Stefan Borgwardt & Alkomiet Hasan      DOI: 10.1007/s00115-024-01608-6 Abstract Despite a very high prevalence and substantial impairments among affected individuals, treatment-resistant schizophrenia (TRS) has not been sufficiently researched in clinical research in the field of psychiatric disorders and the pathophysiology is still poorly understood. A better clinical and pathophysiological …

Management of treatment resistance-Treatment-resistant schizophrenia Read More »

In a recent radio interview with the Offener Kanal Lübeck (Open Channel Lübeck) Marco Heide, the medical head of our Baltic Early Treatment Service (BEATS), elaborated on the service’s help for young people and adolescents experiencing symptoms of psychosis. He highlighted the wide-ranging support this service in Lübeck offers to help-seeking adolescents and adults aged 15-35. …

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Brain texture as a marker of transdiagnostic clinical profiles in patients with recent-onset psychosis and depression Alexandra Korda, Christina Andreou … Stefan Borgwardt & the PRONIA Consortium  DOI: 10.1038/s44220-023-00168-z Abstract The inter-relationships of voxels can be captured by the radiomics texture features across multiple spatial scales. Prediction models of brain texture changes captured by the …

Brain texture as a marker of transdiagnostic clinical profiles in patients with recent-onset psychosis and depression Read More »

Back to the Future: On the Road Towards Precision Psychiatry, Volume II Paul Guest, Stefan Borgwardt & Johann Steiner   DOI: 10.3389/fpsyt.2023.1355085 Abstract However, in the last months of 2019, a new virus was detected in Wuhan China that would wreak havoc around the world for more than two years. This was SARS-CoV-2 which eventually …

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Normative tDCS over V5 and FEF reveals practice-induced modulation of extraretinal smooth pursuit mechanisms, but no specific stimulation effect Jan-Ole Radecke, … Stefan Borgwardt, …  DOI: 10.1038/s41598-023-48313-z Abstract The neural networks subserving smooth pursuit eye movements (SPEM) provide an ideal model for investigating the interaction of sensory processing and motor control during ongoing movements. To …

Normative tDCS over V5 and FEF reveals practice-induced modulation of extraretinal smooth pursuit mechanisms, but no specific stimulation effect Read More »

Basal-Forebrain Cholinergic Nuclei Alterations are Associated With Medication and Cognitive Deficits Across the Schizophrenia Spectrum Julia Schulz, … Stefan Borgwardt … & Mihai Avram   DOI: 10.1093/schbul/sbad118 Abstract Background and Hypothesis The cholinergic system is altered in schizophrenia. Particularly, patients’ volumes of basal-forebrain cholinergic nuclei (BFCN) are lower and correlated with attentional deficits. It is unclear, however, …

Basal-Forebrain Cholinergic Nuclei Alterations are Associated With Medication and Cognitive Deficits Across the Schizophrenia Spectrum Read More »