Publications

Management of treatment resistance-Treatment-resistant schizophrenia

Management of treatment resistance-Treatment-resistant schizophrenia Elias Wagner, Stefan Borgwardt & Alkomiet Hasan      DOI: 10.1007/s00115-024-01608-6 Abstract Despite a very high prevalence and substantial impairments among affected individuals, treatment-resistant schizophrenia (TRS) has not been sufficiently researched in clinical research in the field of psychiatric disorders and the pathophysiology is still poorly understood. A better clinical and pathophysiological …

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Radio interview with the medical head of BEATS Marco Heide

In a recent radio interview with the Offener Kanal Lübeck (Open Channel Lübeck) Marco Heide, the medical head of our Baltic Early Treatment Service (BEATS), elaborated on the service’s help for young people and adolescents experiencing symptoms of psychosis. He highlighted the wide-ranging support this service in Lübeck offers to help-seeking adolescents and adults aged 15-35. …

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Brain texture as a marker of transdiagnostic clinical profiles in patients with recent-onset psychosis and depression

Brain texture as a marker of transdiagnostic clinical profiles in patients with recent-onset psychosis and depression Alexandra Korda, Christina Andreou … Stefan Borgwardt & the PRONIA Consortium  DOI: 10.1038/s44220-023-00168-z Abstract The inter-relationships of voxels can be captured by the radiomics texture features across multiple spatial scales. Prediction models of brain texture changes captured by the …

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Back to the Future: On the Road Towards Precision Psychiatry, Volume II

Back to the Future: On the Road Towards Precision Psychiatry, Volume II Paul Guest, Stefan Borgwardt & Johann Steiner   DOI: 10.3389/fpsyt.2023.1355085 Abstract However, in the last months of 2019, a new virus was detected in Wuhan China that would wreak havoc around the world for more than two years. This was SARS-CoV-2 which eventually …

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Normative tDCS over V5 and FEF reveals practice-induced modulation of extraretinal smooth pursuit mechanisms, but no specific stimulation effect

Normative tDCS over V5 and FEF reveals practice-induced modulation of extraretinal smooth pursuit mechanisms, but no specific stimulation effect Jan-Ole Radecke, … Stefan Borgwardt, …  DOI: 10.1038/s41598-023-48313-z Abstract The neural networks subserving smooth pursuit eye movements (SPEM) provide an ideal model for investigating the interaction of sensory processing and motor control during ongoing movements. To …

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Basal-Forebrain Cholinergic Nuclei Alterations are Associated With Medication and Cognitive Deficits Across the Schizophrenia Spectrum

Basal-Forebrain Cholinergic Nuclei Alterations are Associated With Medication and Cognitive Deficits Across the Schizophrenia Spectrum Julia Schulz, … Stefan Borgwardt … & Mihai Avram   DOI: 10.1093/schbul/sbad118 Abstract Background and Hypothesis The cholinergic system is altered in schizophrenia. Particularly, patients’ volumes of basal-forebrain cholinergic nuclei (BFCN) are lower and correlated with attentional deficits. It is unclear, however, …

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Effective-connectivity of thalamocortical interactions following d-amphetamine, LSD, and MDMA administration

Effective-connectivity of thalamocortical interactions following d-amphetamine, LSD, and MDMA administration Mihai Avram … Helena Rogg, Alexandra Korda … & Stefan Borgwardt 2023, Biological Psychiatry DOI: doi.org/10.1016/j.bpsc.2023.07.010 Abstract Background While the exploration of serotonergic psychedelics as psychiatric medicines deepens, so does the pressure to better understand how these compounds act on the brain. Methods We used …

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NDR radio interview with Prof. Borgwardt on our early detection service BEATS

In a recent radio interview with the NDR Stefan Borgwardt highlighted the wide-ranging support the Baltic Early Treatment Service (BEATS) Lübeck offers to help-seeking adolescents and adults aged 15-35. Referrals can be made by professionals but BEATS also considers self-referrals by help-seeking individuals. For more information on BEATS, please visit our subpage. More information on the …

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The serotonin hypothesis in depression – interview with Prof. Borgwardt

A recent article in The Zeit explores the evidence for the serotonin hypothesis of depression including an interview with Stefan Borgwardt. Specifically, it critically examines the evidence provided by a recent overview article questioning serotonin as a crucial neurotransmitter in the etiology of depression. However, as professor Borgwardt stated, for complex disorders such as depression, …

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The non-specific nature of mental health and structural brain outcomes following childhood trauma

The non-specific nature of mental health and structural brain outcomes following childhood trauma Theresa K Haidl, …. Stefan Borgwardt  2023, Psychol Med DOI: 10.1017/S0033291721002439 Abstract Background: Childhood trauma (CT) is associated with an increased risk of mental health disorders; however, it is unknown whether this represents a diagnosis-specific risk factor for specific psychopathology mediated by …

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