Publications

Brain texture as a marker of transdiagnostic clinical profiles in patients with recent-onset psychosis and depression Alexandra Korda, Christina Andreou … Stefan Borgwardt & the PRONIA Consortium  DOI: 10.1038/s44220-023-00168-z Abstract The inter-relationships of voxels can be captured by the radiomics texture features across multiple spatial scales. Prediction models of brain texture changes captured by the …

Brain texture as a marker of transdiagnostic clinical profiles in patients with recent-onset psychosis and depression Read More »

Back to the Future: On the Road Towards Precision Psychiatry, Volume II Paul Guest, Stefan Borgwardt & Johann Steiner   DOI: 10.3389/fpsyt.2023.1355085 Abstract However, in the last months of 2019, a new virus was detected in Wuhan China that would wreak havoc around the world for more than two years. This was SARS-CoV-2 which eventually …

Back to the Future: On the Road Towards Precision Psychiatry, Volume II Read More »

Normative tDCS over V5 and FEF reveals practice-induced modulation of extraretinal smooth pursuit mechanisms, but no specific stimulation effect Jan-Ole Radecke, … Stefan Borgwardt, …  DOI: 10.1038/s41598-023-48313-z Abstract The neural networks subserving smooth pursuit eye movements (SPEM) provide an ideal model for investigating the interaction of sensory processing and motor control during ongoing movements. To …

Normative tDCS over V5 and FEF reveals practice-induced modulation of extraretinal smooth pursuit mechanisms, but no specific stimulation effect Read More »

Basal-Forebrain Cholinergic Nuclei Alterations are Associated With Medication and Cognitive Deficits Across the Schizophrenia Spectrum Julia Schulz, … Stefan Borgwardt … & Mihai Avram   DOI: 10.1093/schbul/sbad118 Abstract Background and Hypothesis The cholinergic system is altered in schizophrenia. Particularly, patients’ volumes of basal-forebrain cholinergic nuclei (BFCN) are lower and correlated with attentional deficits. It is unclear, however, …

Basal-Forebrain Cholinergic Nuclei Alterations are Associated With Medication and Cognitive Deficits Across the Schizophrenia Spectrum Read More »

Effective-connectivity of thalamocortical interactions following d-amphetamine, LSD, and MDMA administration Mihai Avram … Helena Rogg, Alexandra Korda … & Stefan Borgwardt 2023, Biological Psychiatry DOI: doi.org/10.1016/j.bpsc.2023.07.010 Abstract Background While the exploration of serotonergic psychedelics as psychiatric medicines deepens, so does the pressure to better understand how these compounds act on the brain. Methods We used …

Effective-connectivity of thalamocortical interactions following d-amphetamine, LSD, and MDMA administration Read More »

In a recent radio interview with the NDR Stefan Borgwardt highlighted the wide-ranging support the Baltic Early Treatment Service (BEATS) Lübeck offers to help-seeking adolescents and adults aged 15-35. Referrals can be made by professionals but BEATS also considers self-referrals by help-seeking individuals. For more information on BEATS, please visit our subpage. More information on the …

NDR radio interview with Prof. Borgwardt on our early detection service BEATS Read More »

A recent article in The Zeit explores the evidence for the serotonin hypothesis of depression including an interview with Stefan Borgwardt. Specifically, it critically examines the evidence provided by a recent overview article questioning serotonin as a crucial neurotransmitter in the etiology of depression. However, as professor Borgwardt stated, for complex disorders such as depression, …

The serotonin hypothesis in depression – interview with Prof. Borgwardt Read More »

The non-specific nature of mental health and structural brain outcomes following childhood trauma Theresa K Haidl, …. Stefan Borgwardt  2023, Psychol Med DOI: 10.1017/S0033291721002439 Abstract Background: Childhood trauma (CT) is associated with an increased risk of mental health disorders; however, it is unknown whether this represents a diagnosis-specific risk factor for specific psychopathology mediated by …

The non-specific nature of mental health and structural brain outcomes following childhood trauma Read More »

Chaos analysis of the cortical boundary for the recognition of psychosis Alexandra I. Korda, Christina Andreou, Mihai Avram, Marina Frisman, …, Stefan Borgwardt  2023, J Psychiatry Neurosci DOI: https://doi.org/10.1503/jpn.220160 Abstract Background: Structural MRI studies in people with first-episode psychosis (FEP) and those in the clinical high-risk (CHR) state have consistently shown volumetric abnormalities that depict …

Chaos analysis of the cortical boundary for the recognition of psychosis Read More »

Circadian rhythms in auditory hallucinations and psychosis Hong-Viet V Ngo, … Christina Andreou, …  2023, Acta Physiol DOI: 10.1111/apha.13944 Abstract Circadian rhythms are imprinted in all organisms and influence virtually all aspects of physiology and behavior in adaptation to the 24-h day-night cycle. This recognition of a circadian timekeeping system permeating essentially all healthy functioning …

Circadian rhythms in auditory hallucinations and psychosis. Read More »