Publications

Large-scale brain connectivity changes following the administration of lysergic acid diethylamide, d-amphetamine, and 3,4-methylenedioxyamphetamine Mihai Avram, …, Alexandra Korda, …, Helena Rogg, …, Stefan Borgwardt  DOI: 10.1038/s41380-024-02734-y   Abstract Psychedelics have recently attracted significant attention for their potential to mitigate symptoms associated with various psychiatric disorders. However, the precise neurobiological mechanisms responsible for these effects […]

Serum Metabolites as Potential Markers and Predictors of Depression-like Behavior and Effective Fluoxetine Treatment in Chronically Socially Isolated Rats Dragana Filipović, … , Alexandra Korda, … , Stefan Borgwardt DOI: 10.3390/metabo14080405   Abstract Metabolic perturbation has been associated with depression. An untargeted metabolomics approach using liquid chromatography-high resolution mass spectrometry was employed to detect and

We like to move it – patients with schizophrenia spectrum disorders are impaired in estimating their physical fitness levels and benefit from individualized exercise Wido Rippe, … , Stefan Borgwardt, … DOI: 10.1007/s00406-024-01844-6   Abstract Background: People with schizophrenia spectrum disorders (SSD) engage less in physical activity than healthy individuals. The impact of subjectively assessed physical fitness

Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis Eamonn Kennedy, …, Mihai Avram, …, Stefan Borgwardt, … DOI: 10.3390/brainsci14070669 Abstract Deficits in memory performance have been linked to a wide range of neurological andneuropsychiatric conditions. While many studies have assessed the memory impacts of individ-ual conditions, this study

Which Are the Optimal Screening Tools for Internet Use Disorderin Children and Adolescents? A Systematic Review of PsychometricEvidence Samantha Schlossarek, …, Stefan Borgwardt, … DOI: 10.1007/s40429-024-00568-w Abstract Purpose of Review The early detection of problematic Internet use (PIU) is essential to prevent the development of Internetuse disorders (IUD). Although a variety of screening tools have already

Neurobiologie und Wirkmodelle zu Psychedelika Neurobiology and modes of action of psychedelics Uwe Herwig, Mihai Avram, Stefan Borgwardt, … DOI: 10.1055/a-2261-0745 Zusammenfassung Zur Beantwortung der Frage, ob Psychedelika eine therapeutische Wirkung bei psychischen Erkrankungen aufweisen, ist entscheidend, sich mit möglichen Wirkmechanismen auseinanderzusetzen. Solche können auf psychopharmakologischer, neurobiologischer, neurosystemischer und psychotherapeutischer Ebene beschrieben werden. Neben der klassischen

Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis Inga Meyhoefer, … Stefan Borgwardt, … DOI: 10.1038/s41598-024-64487-6 Abstract Smooth pursuit eye movements are considered a well-established and quantifiable biomarker of sensorimotor function in psychosis research. Identifying psychotic syndromes on an individual level based on neurobiological markers is limited by

Anhedonia as a potential transdiagnostic phenotype with immune-related changes in recent onset mental health disorders Paris Alexandros Lalousis, … Stefan Borgwardt, … DOI: 10.1016/j.biopsych.2024.05.019 Abstract Background Chronic low-grade inflammation is observed across mental disorders and is associated with difficult-to-treat-symptoms of anhedonia and functional brain changes – reflecting a potential transdiagnostic dimension. Previous investigations have focused on distinct

Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study Marco Solmi, … Stefan Borgwardt, … DOI: 10.1016/j.psychres.2024.115972 Abstract International studies measuring wellbeing/multidimensional mental health before/ during the COVID-19 pandemic, including representative samples for >2 years, identifying risk groups and coping strategies are lacking. COH-FIT is an

Distinct Volume Alterations of Thalamic Nuclei Across the Schizophrenia Spectrum Melissa Thalhammer, … Stefan Borgwardt, … Mihai Avram,…  DOI: doi.org/10.1093/schbul/sbae037 Abstract Background and Hypothesis Abnormal thalamic nuclei volumes and their link to cognitive impairments have been observed in schizophrenia. However, whether and how this finding extends to the schizophrenia spectrum is unknown. We hypothesized a distinct