Publications

Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis Inga Meyhoefer, … Stefan Borgwardt, … DOI: 10.1038/s41598-024-64487-6 Abstract Smooth pursuit eye movements are considered a well-established and quantifiable biomarker of sensorimotor function in psychosis research. Identifying psychotic syndromes on an individual level based on neurobiological markers is limited by […]

Anhedonia as a potential transdiagnostic phenotype with immune-related changes in recent onset mental health disorders Paris Alexandros Lalousis, … Stefan Borgwardt, … DOI: 10.1016/j.biopsych.2024.05.019 Abstract Background Chronic low-grade inflammation is observed across mental disorders and is associated with difficult-to-treat-symptoms of anhedonia and functional brain changes – reflecting a potential transdiagnostic dimension. Previous investigations have focused on distinct

Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study Marco Solmi, … Stefan Borgwardt, … DOI: 10.1016/j.psychres.2024.115972 Abstract International studies measuring wellbeing/multidimensional mental health before/ during the COVID-19 pandemic, including representative samples for >2 years, identifying risk groups and coping strategies are lacking. COH-FIT is an

Distinct Volume Alterations of Thalamic Nuclei Across the Schizophrenia Spectrum Melissa Thalhammer, … Stefan Borgwardt, … Mihai Avram,…  DOI: doi.org/10.1093/schbul/sbae037 Abstract Background and Hypothesis Abnormal thalamic nuclei volumes and their link to cognitive impairments have been observed in schizophrenia. However, whether and how this finding extends to the schizophrenia spectrum is unknown. We hypothesized a distinct

Für ein besseres Verständnis anhaltender Wahrnehmungsstörungen nach der Einnahme klassischer Psychedelika Towards a Better understanding of Persisting Perceptual Disturbances following the use of Classic Psychedelics. Mihai Avram, …, Stefan Borgwardt, …    DOI: doi.org/10.1055/a-2264-6472 Klassische Psychedelika wie Psilocybin, Lysergsäurediethylamid (LSD), Ayahuasca oder 5-Methoxy-Dimethyltryptamin (5-MeO-DMT) stehen wieder vermehrt im Fokus des psychiatrisch-psychotherapeutischen und neurowissenschaftlichen Interesses. Dies

Reduced prevalence of drug-related problems in psychiatric inpatients after implementation of a pharmacist-supported computerized physician order entry system – a retrospective cohort study Katharina Wien, …, Stefan Borgwardt DOI: doi.org/10.3389/fpsyt.2024.1304844 Abstract Introduction: In 2021, a computerized physician order entry (CPOE) system with an integrated clinical decision support system (CDSS) was implemented at a tertiary care

Clinical and histopathological characteristics of acute kidney injury in a cohort of brain death donors with procurement biopsies Florian G. Scurt, …, Alexandra Korda, … DOI: https://doi.org/10.1007/s40620-024-01940-9 Abstract Background Kidney biopsies are routinely used for diagnostic and prognostic purposes but their utility in the intensive care unit (ICU) setting is limited. We investigated the associations

Alterations of Functional Connectivity Dynamics in Affective and Psychotic Disorders Linnea Hoheisel, … Stefan Borgwardt, … PRONIA Consortium   DOI: 10.1016/j.bpsc.2024.02.013 Abstract Background Psychosis and depression patients exhibit widespread neurobiological abnormalities. The analysis of dynamic functional connectivity (dFC), allows for the detection of changes in complex brain activity patterns, providing insights into common and unique processes underlying these

  Aging effects on the encoding/retrieval flip in associative memory: fMRI evidence from incidental contingency learning Else Schneider, … Stefan Borgwardt, …  DOI: 10.3389/fnagi.2024.1357695 Summary Associative memory is arguably the most basic memory function and therein constitutes the foundation of all episodic and semantic memory processes. At the same time, the decline of associative memory represents

Normative modelling of brain morphometry across the lifespan with CentileBrain: algorithm benchmarking and model optimisation Ruiyang Ge, … Stefan Borgwardt, …   DOI: 10.1016/S2589-7500(23)00250-9 Summary The value of normative models in research and clinical practice relies on their robustness and a systematic comparison of different modelling algorithms and parameters; however, this has not been done to