Publications

Pattern of predictive features of continued cannabis use in patients with recent-onset psychosis and clinical high-risk for psychosis Nora Penzel,…, Stefan Borgwardt, … DOI: 10.1038/s41537-022-00218-y Abstract Continued cannabis use (CCu) is an important predictor for poor long-term outcomes in psychosis and clinically high-risk patients, but no generalizable model has hitherto been tested for its ability to …

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The Basal Forebrain Cholinergic Nuclei and Their Relevance to Schizophrenia and Other Psychotic Disorders Sofia Eickhoff, Léon Franzen, Alexandra Korda, Helena Rogg, Valerie-Noelle Trulley, Stefan Borgwardt & Mihai Avram   DOI: 10.3389/fpsyt.2022.909961 Abstract The basal forebrain cholinergic nuclei (BFCN) provide the main cholinergic input to prefrontal cortices, the hippocampi, and amygdala. These structures are highly relevant for the regulation and maintenance of many …

The Basal Forebrain Cholinergic Nuclei and Their Relevance to Schizophrenia and Other Psychotic Disorders Read More »

Negative symptoms, striatal dopamine, and model-free reward decision-making in schizophrenia Felix Brandl, …Mihai Avram,… Brain, awac268doi: 10.1093/brain/awac268   Abstract Negative symptoms, such as lack of motivation or social withdrawal, are highly prevalent and debilitating in patients with schizophrenia. Underlying mechanisms of negative symptoms are incompletely understood, thereby preventing the development of targeted treatments. We hypothesized that …

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  Latent state-trait structure of BPRS subscales in clinical high-risk state and first episode psychosis Hochstrasser, L., … S. Borgwardt …    Scientific Reports doi: 10.1038/s41598-022-10207-x   Abstract To investigate the longitudinal latent state-trait structure of the different dimensions of psychosis symptoms in clinical high-risk state (CHRS) and first episode psychosis (FEP) individuals over a one …

Latent state-trait structure of BPRS subscales in clinical high-risk state and first episode psychosis Read More »

Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness Sanfelici, R. … S. Borgwardt … PRONIA Consortium   2022. Cerebral Cortex doi: 10.1093/cercor/bhab288   Abstract Adult gyrification provides a window into coordinated early neurodevelopment when disruptions predispose individuals to psychiatric illness. We hypothesized that the echoes of such disruptions should be observed …

Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness Read More »

Clinical, Brain, and Multilevel Clustering in Early Psychosis and Affective Stages Dwyer, D. B. … C. Andreou … S. Borgwardt … PRONIA Consortium   2022. JAMA Psychiatry doi: 10.1001/jamapsychiatry.2022.1163   Abstract Importance: Approaches are needed to stratify individuals in early psychosis stages beyond positive symptom severity to investigate specificity related to affective and normative variation and …

Clinical, Brain, and Multilevel Clustering in Early Psychosis and Affective Stages Read More »

Neurobiologically Based Stratification of Recent-Onset Depression and Psychosis: Identification of Two Distinct Transdiagnostic Phenotypes Lalousis, P. A. … C. Andreou … S. Borgwardt    2022. Biological Psychiatry doi: 10.1016/j.biopsych.2022.03.021   Abstract Background Identifying neurobiologically based transdiagnostic categories of depression and psychosis may elucidate heterogeneity and provide better candidates for predictive modeling. We aimed to identify …

Neurobiologically Based Stratification of Recent-Onset Depression and Psychosis: Identification of Two Distinct Transdiagnostic Phenotypes Read More »

The relationship between psychological characteristics of patients and their utilization of psychiatric inpatient treatment: A cross-sectional study, using machine learning Lo, S. B. … S. Borgwardt, Lang, U. & Moeller, J.   2022. PLoS One. doi: 10.1371/journal.pone.0266352   Abstract High utilizers (HU) are patients with an above-average use of psychiatric inpatient treatment. A precise characterization …

The relationship between psychological characteristics of patients and their utilization of psychiatric inpatient treatment: A cross-sectional study, using machine learning Read More »

  Special Issue “Psychosis: Clinical Management and Challenges” – call for submissions   We are pleased to invite submissions for special issue with the title “Psychosis: Clinical Management and Challenges” in the Journal of Clinical Medicine, an open access journal by MDPI (IF 4.242), edited by Prof. Christina Andreou in collaboration with Prof. Marco Armando …

Special Issue “Psychosis: Clinical Management and Challenges” – call for submissions Read More »

Increased Belief Instability in Psychotic Disorders Predicts Treatment Response to Metacognitive Training D. J. Hauke, V. Roth, P. Karvelis, R. A. Adams, S. Moritz, S. Borgwardt, A. O. Diaconescu, & C. Andreou   2022. Schizophrenia Bulletin. doi: 10.1093/schbul/sbac029   Abstract Background and Hypothesis: In a complex world, gathering information and adjusting our beliefs about the world …

Increased Belief Instability in Psychotic Disorders Predicts Treatment Response to Metacognitive Training Read More »