Sören Krach

The Basal Forebrain Cholinergic Nuclei and Their Relevance to Schizophrenia and Other Psychotic Disorders Sofia Eickhoff, Léon Franzen, Alexandra Korda, Helena Rogg, Valerie-Noelle Trulley, Stefan Borgwardt & Mihai Avram   DOI: 10.3389/fpsyt.2022.909961 Abstract The basal forebrain cholinergic nuclei (BFCN) provide the main cholinergic input to prefrontal cortices, the hippocampi, and amygdala. These structures are highly relevant for the regulation and maintenance of many […]

Negative symptoms, striatal dopamine, and model-free reward decision-making in schizophrenia Felix Brandl, …Mihai Avram,… Brain, awac268doi: 10.1093/brain/awac268   Abstract Negative symptoms, such as lack of motivation or social withdrawal, are highly prevalent and debilitating in patients with schizophrenia. Underlying mechanisms of negative symptoms are incompletely understood, thereby preventing the development of targeted treatments. We hypothesized that

  Latent state-trait structure of BPRS subscales in clinical high-risk state and first episode psychosis Hochstrasser, L., … S. Borgwardt …    Scientific Reports doi: 10.1038/s41598-022-10207-x   Abstract To investigate the longitudinal latent state-trait structure of the different dimensions of psychosis symptoms in clinical high-risk state (CHRS) and first episode psychosis (FEP) individuals over a one

Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness Sanfelici, R. … S. Borgwardt … PRONIA Consortium   2022. Cerebral Cortex doi: 10.1093/cercor/bhab288   Abstract Adult gyrification provides a window into coordinated early neurodevelopment when disruptions predispose individuals to psychiatric illness. We hypothesized that the echoes of such disruptions should be observed

Clinical, Brain, and Multilevel Clustering in Early Psychosis and Affective Stages Dwyer, D. B. … C. Andreou … S. Borgwardt … PRONIA Consortium   2022. JAMA Psychiatry doi: 10.1001/jamapsychiatry.2022.1163   Abstract Importance: Approaches are needed to stratify individuals in early psychosis stages beyond positive symptom severity to investigate specificity related to affective and normative variation and

Neurobiologically Based Stratification of Recent-Onset Depression and Psychosis: Identification of Two Distinct Transdiagnostic Phenotypes Lalousis, P. A. … C. Andreou … S. Borgwardt    2022. Biological Psychiatry doi: 10.1016/j.biopsych.2022.03.021   Abstract Background Identifying neurobiologically based transdiagnostic categories of depression and psychosis may elucidate heterogeneity and provide better candidates for predictive modeling. We aimed to identify

The relationship between psychological characteristics of patients and their utilization of psychiatric inpatient treatment: A cross-sectional study, using machine learning Lo, S. B. … S. Borgwardt, Lang, U. & Moeller, J.   2022. PLoS One. doi: 10.1371/journal.pone.0266352   Abstract High utilizers (HU) are patients with an above-average use of psychiatric inpatient treatment. A precise characterization

  Special Issue “Psychosis: Clinical Management and Challenges” – call for submissions   We are pleased to invite submissions for special issue with the title “Psychosis: Clinical Management and Challenges” in the Journal of Clinical Medicine, an open access journal by MDPI (IF 4.242), edited by Prof. Christina Andreou in collaboration with Prof. Marco Armando